Compared with imipenem, meropenem and doripenem, the spectrum of activity of ertapenem is more limited primarily because it lacks activity against Pseudomonas aeruginosa and Enterococcus spp.
Where do you inject ertapenem? Ertapenem injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). It is infused (injected slowly) intravenously over a period of at least 30 minutes once or twice a day for up to 14 days.
Similarly, Is ertapenem stronger than meropenem? In general for these target pathogens, based on MIC90 values, ertapenem has similar potency to meropenem and is slightly more potent than imipenem against Gram-negative pathogens whereas imipenem is slightly more potent against Gram-positive pathogens.
Does ertapenem cover MRSA?
Ertapenem is a broad-spectrum carbapenem with a long half-life permitting once-daily dosing. This antibiotic has activity against most invasive bacterial pathogens except for methicillin-resistant Staphylococcus aureus (MRSA), enterococci, Pseudomonas aeruginosa, and Acinetobacter baumannii.
What is the half-life of ertapenem?
Ertapenem is eliminated primarily by the kidneys. The mean plasma half-life in healthy young adults is approximately 4 hours and the plasma clearance is approximately 1.8 L/hour.
How long is ertapenem IV good for?
DOSAGE AND ADMINISTRATION
INVANZ may be administered by intravenous infusion for up to 14 days or intramuscular injection for up to 7 days.
How long does ertapenem stay in your body? How long does ertapenem (Invanz) stay in your system? After you take a single dose of ertapenem (Invanz), if you have good kidney function, less than 5% of the medication will be left in your body after 24 hours.
How long does ertapenem stay in your system? Ertapenem is eliminated primarily by the kidneys. The mean plasma half-life in healthy young adults is approximately 4 hours and the plasma clearance is approximately 1.8 L/hour.
What makes ertapenem different from other carbapenems?
This in vitro data suggest that ertapenem is less stable than the other carbapenems to the beta-lactamase enzymes and may confer resistance more rapidly in vivo. P. aeruginosa has become resistant to many of the beta-lactam antibiotics. It remains fairly sensitive to the carbapenems, excluding ertapenem.
Does ertapenem cover E coli? Several in vitro studies have evaluated ertapenem and have shown excellent in vitro susceptibility to ESBL-producing Escherichia coli and Klebsiella pneumoniae with comparable MIC 90 to that of group 2 carbapenems.
Is ertapenem oral?
Ertapenem (Invanz, Merck) is FDA-approved for intravenous (IV) or intramuscular (IM) use for the “treatment of moderate to severe infections caused by susceptible bacteria”. It is supplied as a lyophilized powder in a vial, which requires reconstitution for IV/IM administration.
Does ertapenem make you tired? Trouble controlling body movements. Feeling very sleepy. Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen.
What bacteria does ertapenem cover?
Ertapenem, a carbapenem antibacterial, has in vitro activity against many Gram- negative (including Enterobacteriaceae) and Gram-positive aerobic and anaerobic bacteria that are commonly associated with various infections.
Does ertapenem treat MSSA?
Ertapenem and cefazolin were used in combination to successfully clear refractory methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. In addition, recent work has demonstrated activity of combination therapy with beta-lactams from different classes against methicillin-resistant S. aureus (MRSA).
How long does IV ertapenem stay in your system? How long does ertapenem (Invanz) stay in your system? After you take a single dose of ertapenem (Invanz), if you have good kidney function, less than 5% of the medication will be left in your body after 24 hours.
What is the pH of ertapenem?
The sodium content is approximately 137 mg (approximately 6.0 mEq). Each vial of INVANZ contains the following inactive ingredients: 175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5.
What is the other name for ertapenem?
Ertapenem (trade name Invanz) is a carbapenem antibiotic medication for the treatment of infections of the abdomen, the lungs, the upper part of the female reproductive system, and diabetic foot, used in the form of infusions or injections.
Is ertapenem hard on the kidneys? Background: Ertapenem is a broad-spectrum and long-acting carbapenem which is predominantly eliminated by the kidneys, and it requires dose adjustment in renal failure.
How effective is ertapenem?
In patients with CAP, clinical cure rates were 95% (19 of 20) for ertapenem and 88.9% (16 of 18) for ceftriaxone. Conclusion: Ertapenem therapy was as effective as either piperacillin-tazobactam or ceftriaxone for serious infections caused by Enterobacteriaceae.
What does ertapenem do to the body? Ertapenem is used alone or in combination with other antibiotics to treat infections caused by bacteria in many different parts of the body. It works by killing bacteria or preventing their growth.
Does ertapenem cover Enterobacter?
Geometric mean MICs of ertapenem for the collection were reduced five-fold by clavulanic acid for Klebsiella spp. compared with eight-fold by cloxacillin for Enterobacter spp. This study highlights the fact that ertapenem resistance is being detected in Klebsiella spp. and Enterobacter spp.
Does ertapenem treat Enterococcus? Piperacillin activity is similar to that of penicillin, and imipenem generally is active against penicillin-susceptible E. faecalis. Cell wall-active agents with limited or no activity against enterococci include nafcillin, oxacillin, ticarcillin, ertapenem, most cephalosporins, and aztreonam.