The major metabolite of ertapenem is the inactive ring- opened derivative formed by hydrolysis of the beta-lactam ring. In vitro studies in human liver microsomes indicate that ertapenem does not inhibit metabolism mediated by any of the following cytochrome p450 (CYP) isoforms: 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4.
Where is ertapenem metabolized? Ertapenem
| Clinical data | |
|---|---|
| Metabolism | Hydrolysis of beta-lactam ring, CYP not involved |
| Elimination half-life | 4 hours |
| Excretion | Kidney (80%) and fecal (10%) |
| Identifiers |
Similarly, How long does Invanz stay in your system? How long does ertapenem (Invanz) stay in your system? After you take a single dose of ertapenem (Invanz), if you have good kidney function, less than 5% of the medication will be left in your body after 24 hours.
Is ertapenem hard on the kidneys?
Background: Ertapenem is a broad-spectrum and long-acting carbapenem which is predominantly eliminated by the kidneys, and it requires dose adjustment in renal failure.
What is the pH of ertapenem?
The sodium content is approximately 137 mg (approximately 6.0 mEq). Each vial of INVANZ contains the following inactive ingredients: 175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5.
Can you push IV ertapenem?
Several antibiotics are Food and Drug Administration–approved for IV push administration, including many beta-lactams. In addition, cefepime, ceftriaxone, ertapenem, gentamicin, and tobramycin have primary literature data to support IV push administration.
Does ertapenem cover Serratia? Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Citrobacter spp., Klebsiella spp., Serratia spp., Proteus …
Is Proteus mirabilis sensitive to ertapenem? mirabilis. These results support the potent in vitro bactericidal activity of ertapenem against all multiresistant strains selected in this study and the use of this drug in the treatment of intra-abdominal infections.
Does ertapenem cover Pseudomonas?
Compared with imipenem, meropenem and doripenem, the spectrum of activity of ertapenem is more limited primarily because it lacks activity against Pseudomonas aeruginosa and Enterococcus spp.
What happens when you push IV meds too fast? Too rapid administration of high doses (greater than 500 mg administered over less than 10 minutes) may precipitate hypotension, cardiac arrhythmia and sudden death.
How long is ertapenem stable after mixing?
When prepared with the diluent, INVANZ (Ertapenem for Injection) maintains satisfactory potency for 6 hours at room temperature (25°C) or for 24 hours under refrigeration (5°C) and used within 4 hours after removal from refrigeration. Solutions of INVANZ should not be frozen.
How do you shoot ertapenem? Ertapenem injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). It is infused (injected slowly) intravenously over a period of at least 30 minutes once or twice a day for up to 14 days.
Does ertapenem cover enterococcus?
Piperacillin activity is similar to that of penicillin, and imipenem generally is active against penicillin-susceptible E. faecalis. Cell wall-active agents with limited or no activity against enterococci include nafcillin, oxacillin, ticarcillin, ertapenem, most cephalosporins, and aztreonam.
Does ertapenem cover Lactobacillus?
However, it is not active against Pseudomonas aeruginosa, Acinetobacter spp., Stenotrophomonas maltophilia, Burkholderia cepacia, and Aeromonas spp., entorococci, MRSA, penicillin-resistant Streptococcus pneumoniae, Clostridium difficile and Lactobacillus spp.
Does ertapenem cover group B strep? Ertapenem is a novel carbapenem reported to have activity against gram-positive bacteria similar to that of meropenem (16, 17). Linezolid, ertapenem, and quinupristin-dalfopristin all proved to be highly active in vitro against all of the GBS isolates tested.
Does ertapenem cover E faecalis?
Ertapenem is a broad-spectrum antibiotic with activity against a range of gram-positive, gram-negative, and anaerobic gastrointestinal organisms but with limited activity against E. faecalis [4, 5].
Is ertapenem broad-spectrum?
Spectrum: Like its big brother (Imipenem), ertapenem has a very broad spectrum of activity that includes all anaerobes and many aerobic gram-positive and gram-negative organisms. It has poor activity against P aeruginosa and Acinetobacter and lacks activity against Enterococcus faecium, S. epidermidis, B. Lepacia, S.
Does ertapenem cover Enterobacter? Geometric mean MICs of ertapenem for the collection were reduced five-fold by clavulanic acid for Klebsiella spp. compared with eight-fold by cloxacillin for Enterobacter spp. This study highlights the fact that ertapenem resistance is being detected in Klebsiella spp. and Enterobacter spp.
Does ertapenem cover E coli?
Several in vitro studies have evaluated ertapenem and have shown excellent in vitro susceptibility to ESBL-producing Escherichia coli and Klebsiella pneumoniae with comparable MIC 90 to that of group 2 carbapenems.
What bacteria does ertapenem not cover? Spectrum: Like its big brother (Imipenem), ertapenem has a very broad spectrum of activity that includes all anaerobes and many aerobic gram-positive and gram-negative organisms. It has poor activity against P aeruginosa and Acinetobacter and lacks activity against Enterococcus faecium, S. epidermidis, B. Lepacia, S.
What drug should never be given IV push?
The most common medications not provided in ready-to-administer syringes include: Antiemetics Antibiotics with short stability Metoprolol Antipsychotics Opioids Furosemide Benzodiazepines Pantoprazole These medications are available in a prefilled syringe, however supply has been limited.
Does IV go in artery or vein? A healthcare provider, usually a nurse, will locate a vein for the IV site and insert a cannula, a device that moves substances into the bloodstream. IVs are always placed in veins, not arteries, allowing the medication to move through the bloodstream to the heart.
What are two of the most common IV equipment complications?
Risks and side effects
- Inflammation. One of the most common complications of IV injections is inflammation of the vein, or phlebitis. …
- Drug irritation. Direct injection of a drug into a peripheral vein can cause irritation and inflammation in surrounding tissues. …
- Bruising. …
- Drug extravasation. …
- Infection. …
- Central line issues.
How long does ertapenem last? Store the medicine that has been mixed at room temperature and use it within 6 hours. You may also store this mixture for 24 hours in the refrigerator and use it within 4 hours after removing from the refrigerator. Throw away any mixed medicine that has not been used within this time. Do not freeze the solution .
How is ertapenem reconstituted?
(IV): Reconstitute 1 gram vial with 10 mL of Water for Injection, 0.9% Sodium Chloride Injection, or Bacteriostatic Water for Injection and then add contents to 50 ml normal saline. Complete the infusion within 6 hours of reconstitution.
Can ertapenem be mixed with lidocaine? Ertapenem, reconstituted with 1% lidocaine HCl injection, USP (in saline without epinephrine), is almost completely absorbed following intramuscular (IM) administration at the recommended dose of 1 g. The mean bioavailability is approximately 90%.