Miconazole and clotrimazole, members of a class of imidazole agents which have broad spectrum antimycotic activity, were shown to be potent inhibitors of steroid aromatase activity of human placental microsomes. … The inhibition of aromatase activity by miconazole was shown to be reversible by dilution.
Simply so, Can imidazole be protonated? Protonation of gaseous imidazole is predicted to occur exclusively at the N-3 imine nitrogen to yield a stable aromatic cation. Proton affinities in imidazole are calculated as 941, 804, 791, 791 and 724 for the N-3, C-4, C-2, C-5 and N-1 positions, respectively.
Why is imidazole a base? Explain why N1 of imidazole is most basic
In the cyclic structure, there are 2 pi bonds (between C2-C3 and N1-C5) and one lone pair on N4 that can interact with each other to form a delocalised pi system. … Therefore the lone pair will be available for donation, which makes N1 the strongest base in this question.
Subsequently, What is imidazole alkaloid?
Imidazole alkaloids contain an imidazole nucleus and are derived from histidine. They are found in various Pilocarpus species (Rutaceae) and fungi, e.g., ergothioneine and hercynine. A number of imidazole alkaloids found in marine sponges have been reviewed. 202,203.
How do you say imidazoles?
Is imidazole more basic than pyridine? Imidazole is an aromatic ring found in many biological molecules. One of its nitrogen atoms resembles that of pyrrole, and is not basic. The second nitrogen atom, which is structurally similar to the nitrogen atom of pyridine, acts as a base. However, imidazole is about 100 times more basic than pyridine.
Is imidazole more basic than pyrrole?
Imidazole is over a million times more basic than pyrrole because the sp2 nitrogen that is part of one double bond is structurally similar to pyridine, and has a comparable basicity.
Is Pyrazine a functional group? Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. It is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine.
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CHEBI:30953 – pyrazine.
| ChEBI Name | pyrazine |
|---|---|
| Stars | This entity has been manually annotated by the ChEBI Team. |
• Sep 24, 2014
Why do we use imidazole in protein purification?
Imidazole is utilized as a competitive agent for elution of histidine-tagged proteins. In addition, imidazole can be added in low concentrations in the sample and binding buffer in order to reduce the binding of contaminant proteins, and thus increase the final purity.
Is imidazole a weak base? Imidazole is an aromatic ring found in many biological molecules. One of its nitrogen atoms resembles that of pyrrole, and is not basic. The second nitrogen atom, which is structurally similar to the nitrogen atom of pyridine, acts as a base. However, imidazole is about 100 times more basic than pyridine.
How is imidazole aromatic?
Imidazole. Imidazole is another five-membered heterocyclic ring which has 6 pi electrons and is aromatic. Both of the nitrogen atoms are sp2 hybridized. One nitrogen is pyridine-like because it is part of a double bond and adds one pi electron to the aromatic pi ring.
What is imidazole antifungal? Definition. Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.
Why is imidazole more basic than pyridine?
Imidazole is more basic than pyridine. This is due to the greater resonance stabilization of the positive charge of its conjugate acid. Greater the pka value, the more basic the species become.
How do you pronounce pyrimidine?
How do you pronounce triazoles?
- Phonetic spelling of triazole. tri-a-zole. trahy-uh-zohl.
- Meanings for triazole. It is a chemical compound, which is used to treat a variety of bacterial infections.
- Synonyms for triazole. triazolo.
- Translations of triazole. Indonesian : triazol. Japanese : トリアゾール Chinese : 三唑 Arabic : الترايازول Spanish : triazol.
How do you pronounce Nystop?
Why is imidazole more basic than Oxazole?
The oxygen atom of oxazole decreases the electron density at the nitrogen atom by an inductive effect. Thus, the oxazole is a weaker base than thiazole. Sulfur is less electronegative than oxygen and inductively is a weaker electron withdrawing atom. Explain why pyrazole is a weaker base than imidazole.
Why is imidazole more basic than pyrazole? Pyrazole is a weaker base than Imidazole. This is due to the sp2 orbital of nitrogen is the site of protonation in both pyrazole and imidazole. The nitrogen atom bonded to hydrogen is not basic because its lone pair of electrons is part of the aromatic ring system.
Which heterocycles are more basic than pyrrole?
Pyridine is more basic than pyrrole.
Is imidazole a strong Nucleophile? Nitrogen is a better electron donor than carbon and thus is more nucleophilic. Imidazole is an N-nucleophile.
Which is more acidic pyrrole or imidazole?
The lone pair of electrons in the sp2 orbital of pyrrole is a part of the cloud. Hence it less acidic than imidazole.
Is methyl a functional group? The methyl group is the only nonpolar functional group in our class list above. The methyl group consists of a carbon atom bound to three hydrogen atoms.
What is pteridine ring explain?
[ tĕr′ĭ-dēn′ ] Any of a group of organic compounds having two fused six-member rings each containing two nitrogen atoms and four carbon atoms. One of the rings is a pyrimidine, the other a pyrazine. Pteridines include folic acid and the pigments of butterfly wings.
What was pyrazine used for? Methoxylated pyrazines are mainly used in the perfume industry to improve the odor of cosmetics and toiletries (fresh, green, woody, ambery, oriental, musky, minty, and herbaceous). Pyrazine flavors are often added to microwave foods because roasting odors are not formed in microwaves at temperatures below 200 °C.
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